An Overview oif the Subsys Fentanyl Spray

Subsys is the first and only spray for breaktrhough cancer pain. The idea behind it is to help manage the intense and rapid flare-ups of pain in cancer patients by providing relief in as little as 5 minutes. It contains fentanyl and is sprayed and absorbed underneath the tongue. According to the website of Williams Kherkher, it is 100 times more potent than morphine as a painkiller.

Given its potential formisuse, abuse, addicition, and overdose, Subsys is only available through the Transmucosal Immediate Release Fentanyl (TIRF) Risk Evaluation and Mitigation Strategy (REMS) Access program. Prior to taking the drug, you first need to understand the benefits and risks of Subsys, agree to all the instructions, and sign the Patient-Prescriber Agreement form. Launched in the market ion 2012, Subsys was specifically approved for the management of breakthrough pain.

Subsys spray is available in 100 mcg, 200 mcg, 400 mcg, 600 mcg, and 800 mcg variants. Abuse or medication errors of fentanyl subject the patient to risks of respiratory depression. Replacement of subsys with other fentanyl containing products may cause fatal overdose. Fentanyl is a Schedule II controlled substance, with abuse liability similar to other opioid analgesics. To be able to prescribe subsys, a healthcare provider must be enrolled in the TIRF REMS Access program.

Subsys should not be used when the following conditions are met:

Patient is not opioid tolerant
For short term pain that you expect to go away in a few days
If you are allergic to any of the ingredients in Subsys
Before taking Subsys, you should inform your provider of the following:
Sores or ulcers in the mouth
Breathing problems or lung issues such as asthma, wheezing, or shortness of breath
History of head injury or brain problem
Liver or kidney problems
Slow heart rate or other health problems
Mental health problems
Previous drinking problem
Other health conditions

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